Can multidrug-resistant microbes trap in molecular glue?


 Can multi drug-resistant microbes trap in molecular glue?

Multiple drug resistance (MDR), is the microorganisms that are resistant to an antimicrobial drug. These microbes are most threatening to public health. MDR microbes can resist multiple antibiotics; other types include MDR bacteria, viruses, fungi, and parasites (resistant to multiple antibacterial, antifungal, antiviral, and anti-parasitic drugs of a wide chemical variety).
Around the world bacteria are evolving new approaches that help to render them resistant to antibiotics, resulting in a growing number of patients dying from untreatable infections. Scientists are now focusing to discover new medicines soon, otherwise the post-antibiotic era may be upon us, effectively pushing human healthcare back to the 1940s.The most causative class of bacteria are 'Gram-negative bacteria', which include the most common & well-known species E. coli, are causing major problems in our hospitals.


The problem is that microorganisms have lasted for thousands of years by their capability to adapt to antimicrobial agents which takes place due to spontaneous mutation or by DNA transfer. This process allows some bacteria to face the action of certain antibiotics, rendering the antibiotics ineffective. Most antibiotics that we know today work according to only a few mechanisms of action and so when a bacterium develops tolerant to one drug, it often becomes tolerant of the whole family of drug type. The only solution to deal with the situation is to develop an entirely new class of drugs that share no structural or mechanistic similarities with the existing antibiotics.
These drugs penetrate bacterial cells and induce a process called protein aggregation. In this process, the bacterial proteins that normally carry out essential functions for the bacteria - such as digesting their food,  clump together and can no longer carry out their work which affects many proteins in the bacterial cell all at once, the bacteria rapidly succumb and die.

For more details : https://bacteriology.infectiousconferences.com/ 


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